Supported by Yokohama NMR Association
■開催日：2022年10月27日（木）～28日（金）
■開催場所：理化学研究所・横浜研究所交流棟ホール
■プログラム
<October 27 (Thu), 2022>
10:00-10:10 Introduction
10:10-11:10 Cristian Hilty (TAM)
Measuring Affinity and Structure in Protein-Ligand Interactions using Hyperpolarized NMR.
11:10-11:40 Kenji Sugase (Kyoto Univ.)
High-sensitivity Rheo-NMR
11:40-12:10 Takanori Kigawa (RIKEN)
The molecular mechanism of glycolytic flux control revealed by NMR analysis of human PGK in the intracellular environment
12:10-12:40 Hideo Takahashi (YCU)
Solution NMR analysis of a light-driven membrane protein
12:40-13:40 Lunch
13:40-14:10 Yoshifumi Nishimura (YCU)
Histone tail network and modulation in a nucleosome.
14:10-14:40 Shin-ichi Tate (Hiroshima Univ.)
Structure dynamics of intrinsically disordred proteins and their biological roles explored by NMR
14:40-15:10 Koh Takeuchi (UTokyo)
Utilization of NMR dynamics information to improve protein druggability
15:10-15:40 Gota Kawai (CIT)
Interaction analysis between small molecules and RNAs toward the RNA-targeted drug discovery
15:40-16:00 Intermission
16:00-16:30 Hiroki Yamaguchi (Ajinomoto Co.)
Structural biology for development of industrial enzymes: Recent advance of enzyme engineering using Cryo-EM.
16:30-17:00 Shuhei Kishikawa (Daiichi-Sankyo RD Novare)
Fragment based approach for hit discovery with 19F-NMR and biophysics
17:00-18:00 Wolfgang Jahnke (Novartis, Switzerland)
Drug discovery and mechanistic understanding of drug targets by NMR.
18:30-20:30 Banquet at Yone-zushi (Fees: 6,000 JPY)
<October 28 (Fri), 2022>
9:30-10:30 Mitsuhiko Ikura (Univ. Toronto, Canada)
Mechanistic studies on RAS signaling at the membrane surface
10:30-11:00 Shunsuke Imai (RIKEN)
Structural equilibrium underlying ligand-dependent activation of beta2-adrenoreceptor
11:00-11:30 Chojiro Kojima (YNU)
NMR tools developed for drug discovery and its application to DNA targeting small molecules
11:30-12:00 Taichi Sakamoto (CIT)
Biophysical study of the aptamer that binds to a target protein
12:00-12:30 Yutaka Ito (TMU)
Protein structure determination by NMR: conformational multiplicity and the effects of macromolecular crowding
12:30-13:30 Lunch
13:30-14:00 Masato Katahira (Kyoto Univ.)
Structure, base pair opening dynamics and interaction with Tat of DNA/RNA in living human cells as revealed by in-cell NMR
14:00-14:30 Masanori Osawa (Keio Univ.)
Paip2A inhibits translation by competitively binding to poly(A)-binding protein C1 and promoting its dissociation from the poly(A) tail
14:30-15:00 Takahisa Ikegami (YCU)
Analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria
15:00-15:30 Seizo Koshiba (Tohoku Univ.)
Tohoku Medical Megabank cohort project: Multi-omics study for population health
15:30-15:50 Intermission
15:50-16:20 Saeko Yanaka (Kyushu Univ.)
Integrative approach for the observation of conformational dynamics and interactions of antibodies
16:20-16:50 Naohiro Kobayashi (RIKEN)
NMR analysis of protein complex assisted by machine learning
16:50-17:50 Peter Wright (Scripps, USA)
Role of dynamic protein disorder in regulating the cellular response to genotoxic and hypoxic stress
17:50-18:00 Closing
■参加費：よこはまNMR研究会正会員は無料/非会員5,000円
詳細については下記URLをご参照ください
http://www.tsurumi.yokohama-cu.ac.jp/ynmr/workshop.html
■お問い合わせ：
よこはまＮＭＲ研究会 事務局 （代表：西村善文）
横浜市立大学大学院生命医科学研究科 西村研究室内
〒230-0045 神奈川県横浜市鶴見区末広町1-7-29
TEL:045-508-7211/7381（直通）
FAX:045-508-7360
E-mail: yokohamanmr＠yokohama-cu.ac.jp
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Webサイト: http://www.tsurumi.yokohama-cu.ac.jp/ynmr/
